{"created":"2023-05-15T08:48:42.858648+00:00","id":101,"links":{},"metadata":{"_buckets":{"deposit":"77364475-1ba2-46f6-b567-579116fdba12"},"_deposit":{"created_by":4,"id":"101","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"101"},"status":"published"},"_oai":{"id":"oai:kawasakigakuen.repo.nii.ac.jp:00000101","sets":["5:20"]},"author_link":["107","221","173","218","1"],"control_number":"101","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"59","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"大阪河﨑リハビリテーション大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Osaka Kawasaki Rehabilitation University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Disuse muscle atrophy may be induced by both qualitative and quantitative inactivity in elderly psychiatric patients resulting from restriction of activity or psychiatric drugs. In order to clarify the early stage of disuse muscle atrophy in elderly patients, we examined serum creatinine (Cr) and serum albumin (Alb) in elderly psychiatric patients divided into two groups: those who were capable of walking (group A) and those in a bed-ridden state (group B). We then measured Cr and Alb levels once a month, and serum Cr and Alb values were compared between the two groups. Cr and Alb values were significantly decreased (p<0.01) in group B compared with group A. The simultaneous reduction of Cr and Alb in these patients indicated disuse muscle atrophy due to inhibition of mitochondrial creatine kinase activity in muscle cells. The measurement of Cr and Alb values may be a useful tool to analyze deterioration in disuse muscle atrophy in psychiatric patients. Furthermore, this may lead to improvements in rehabilitation to prevent whole body disuse muscle atrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"精神障害入院患者では、疾患特異性、薬剤の影響、運動量の質的量的変化により、廃用性筋萎縮を生じ全身状態が悪化すると考えられる。治療のため、長期入院が必要となる患者においては、長期となるがゆえに身体機能低下が助長される。精神障害長期入院の患者の廃用性筋萎縮の機構の一端を知るために、34 例（男性17 例、平均年齢70.7 ± 11.0 歳、女性17 例、平均年齢76.4 ± 10.5歳、入院期間は約2 年以上）の患者を歩行可能群と歩行困難群とに分類し、月1 回のルーチン検査として行われている血清クレアチニン（Cr）値と血清アルブミン（Alb）値をそれぞれ歩行可能群と歩行困難群とで比較した。血清Cr 値および血清Alb 値は共に歩行困難群では歩行可能患群に比べて有意に低値を示した（P<0.01）。これは、筋萎縮により筋細胞のミトコンドリアクレアチンキナーゼ（CPK）活性が抑制されたため、血清Cr 値が低下し、また同時に血清Alb 値の合成が低下したためであると推察した。本結果より、血清Cr 値および血清Alb 値の低下は歩行困難となりうる廃用性筋萎縮の移行を推測し、初期に廃用性筋萎縮を発見できる可能性を示している。血清Cr 値と血清Alb 値の低下の見られる患者に対して廃用性筋萎縮を防止する適切な運動療法を行うことで、廃用性筋萎縮による歩行困難や全身状態悪化を予防し得ると考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容種別","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"大阪河﨑リハビリテーション大学","subitem_publisher_language":"ja"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"40019449907","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12235266","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-509X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久利 彩子","creatorNameLang":"ja"},{"creatorName":"Ayako　HISARI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村西 壽祥","creatorNameLang":"ja"},{"creatorName":"Hisayoshi MURANISHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中柗 俊介","creatorNameLang":"ja"},{"creatorName":"Shunsuke NAKAMATSU","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大田 喜一郎","creatorNameLang":"ja"},{"creatorName":"Kiichiro OTA","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小西 正良","creatorNameLang":"ja"},{"creatorName":"Masayoshi KONISHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-09"}],"displaytype":"detail","filename":"Ｋ0701-059-064.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ｋ0701-059-064","url":"https://kawasakigakuen.repo.nii.ac.jp/record/101/files/Ｋ0701-059-064.pdf"},"version_id":"26d1db31-1047-4666-b617-08b86b0e7949"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"精神障害","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"入院患者","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"廃用性筋萎縮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"クレアチニン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アルブミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"psychiatric patients","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inpatient","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum creatinine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"disuse muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"精神障害入院患者の廃用性筋萎縮の生化学的指標について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"精神障害入院患者の廃用性筋萎縮の生化学的指標について","subitem_title_language":"ja"},{"subitem_title":"Biochemical indicators of disuse atrophy in hospitalized patients with mental disorders","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"4","path":["20"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-09"},"publish_date":"2020-06-09","publish_status":"0","recid":"101","relation_version_is_last":true,"title":["精神障害入院患者の廃用性筋萎縮の生化学的指標について"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-09-29T02:41:09.046643+00:00"}