@misc{oai:kawasakigakuen.repo.nii.ac.jp:00000329,
 author = {Misa NAKAMURA and Masakazu IMAOKA and Hiroshi HASHIZUME and Fumie TAZAKI and Hidetoshi NAKAO and Mitsumasa HIDA and Tomoko OMIZU and Hideki KANEMOTO and Ichiro KAMEI and Masatoshi TAKEDA},
 month = {Dec},
 note = {Many reports show that low bone mineral density and osteoporosis are associated with cognitive impairment and Alzheimer's disease in older women. In addition, bone-related substances such as osteocalcin (OC) and insulin-like growth factor 1 (IGF-1) affect cognitive function. In this study, the aim was to clarify the relationship between changes in cognitive function and changes in serum OC, IGF-1, and albumin levels in community-dwelling older people. The participants were 76 healthy older people living in Japan. They participated in a weekly, local government-supported exercise class for 13 weeks. The Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. Twenty-two participants (28.9%) had decreased MMSE scores at the 13th week. Correlation analysis showed that ΔOC correlated with ΔMMSE score. On analysis of covariance adjusted for baseline values, the cognitive decline group had a significantly greater decrease in OC levels than the no cognitive decline group. The participants with increased ΔOC had lower odds of cognitive decline at the 13th week on logistic regression analysis. These results suggest that there may be a relationship between decreases in serum OC levels and cognitive decline in community-dwelling older people., Original Article},
 title = {Association between cognitive decline and decreased serum osteocalcin levels in community-dwelling older people},
 year = {2021}
}