{"created":"2023-05-15T08:48:53.387400+00:00","id":356,"links":{},"metadata":{"_buckets":{"deposit":"4509262d-4de2-4bfc-b19f-6cd468f18142"},"_deposit":{"created_by":4,"id":"356","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"356"},"status":"published"},"_oai":{"id":"oai:kawasakigakuen.repo.nii.ac.jp:00000356","sets":["5:36"]},"author_link":["450"],"control_number":"356","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"9","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"大阪河﨑リハビリテーション大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Osaka Kawasaki Rehabilitation University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"レスベラトロールはブドウの果皮に多いポリフェノールで、 ブドウを丸ごと使用して作られる赤ワインにも多い。 レスベラトロールは寿命を延ばす遺伝子(サーチュイン)を活性化し、 さらに細胞のエネルギーが減少するとミトコンドリアを活性化するAMPKも活性化、 また細胞の古くなった小器官や成分を分解し細胞内を浄化するオートファジーも活性化させる。 レスベラトロールにより、 酵母や無脊椎動物では寿命が延び、 マウスではインスリン抵抗性や動脈硬化に関連する加齢性徴候が改善される。 また、 適量飲酒の作用として、 血小板の凝集抑制、 HDLコレステロールの増加、 血糖値の低下などがあり、 飲酒そのものにも心筋梗塞や糖尿病の予防効果がみられる。 これらの作用はレスベラトロールにもある。 レスベラトロールは脂溶性物質でアルコールと共に摂取すると体内に吸収されやすい。 赤ワインでのレスベラトロールとアルコールの相乗効果により健康寿命を延ばすことが期待される。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Resveratrol is a polyphenol present in grape skin and found in red wine produced from grape with skin. Resveratrol activates the anti-aging gene sirtuin; and AMP-activated protein kinase, which promotes mitochondrial functions if cellular energy is lowered; and autophagy, that is engaged in cleaning of the inside of a cell by degrading older or damaged cellular components. More importantly, resveratrol extends the lifespan of yeast and invertebrates and improves age-related signs in mice, especially those signs connected with insulin resistance and arteriosclerosis. Moderate alcohol consumption inhibits platelet aggregation, increases HDL cholesterol, and lowers blood sugar, meaning that ethanol protects cardiac infarction or diabetes. Further, resveratrol has more such beneficial effects. Since resveratrol is lipophilic, it is absorbed into the body more easily when taken with alcohol. Altogether, red wine, due to its synergistic effect caused by resveratrol and alcohol, could extend healthspan.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容種別","attribute_value_mlt":[{"subitem_description":"Review Article","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"大阪河﨑リハビリテーション大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-509X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"後藤 隆洋","creatorNameLang":"ja"},{"creatorName":"Takahiro GOTOW","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-01"}],"displaytype":"detail","filename":"K 16-009-025.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"K 16-009-025","url":"https://kawasakigakuen.repo.nii.ac.jp/record/356/files/K 16-009-025.pdf"},"version_id":"3cb8d280-0a77-4a9b-86bd-282bfd6f6b62"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"寿命","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"レスベラトロール","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サーチュイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"赤ワイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"lifespan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sirtuin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"red wine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"レスベラトロールと赤ワインは健康寿命を延ばす","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レスベラトロールと赤ワインは健康寿命を延ばす","subitem_title_language":"ja"},{"subitem_title":"Resveratrol and Red Wine Improve Healthspan","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"4","path":["36"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-01"},"publish_date":"2022-06-01","publish_status":"0","recid":"356","relation_version_is_last":true,"title":["レスベラトロールと赤ワインは健康寿命を延ばす"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-09-29T07:46:11.654405+00:00"}