{"created":"2023-05-15T08:48:41.685309+00:00","id":76,"links":{},"metadata":{"_buckets":{"deposit":"d0b5c4cc-70e6-49f6-a70d-4a90860c81d8"},"_deposit":{"created_by":4,"id":"76","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"76"},"status":"published"},"_oai":{"id":"oai:kawasakigakuen.repo.nii.ac.jp:00000076","sets":["5:19"]},"author_link":["1","218"],"control_number":"76","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"17","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"大阪河﨑リハビリテーション大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Osaka Kawasaki Rehabilitation University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Professor Dr. Ota, who is the Manager of department rehabilitation research center, stated on research directionality. We surveyed knowledge about muscular tissues of human body. A smooth muscle, cardiac muscle and striated muscle consisting of the human body show specific function and morphology. These constructing mechanisms are different in details, but all muscles show myofibril shortening is caused by the myosin filaments sliding past the actin thin filaments, with no change in the length of either type of filament. The reproduction abilities are low in these muscles. In mouse, there is a report on renew and regeneration of cardiac muscle fibers, recently. We hope a success that new myocardium derived from Embryonic stem cells (ESC) or Induced pluripotent stem cells (iPSC) is continued heartbeat in vivo. In addition, atrophy is seen in a striated muscle. It depends on lesion of musculo-skeletal or a neurologic system, and E3 ubiquitin ligase is accepted commonly in sarcoplasm of atrophic muscle. We expect the recovery of the patient, independence to a daily life, and improvement of the QOL by appropriate correspondences.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"初代精神科リハビリテーション研究センター長の大田喜一郎教授が研究の方向性を示されたことを受けて、ヒトの筋組織についての知見を概述した。ヒトの身体を構成する平滑筋、心筋および横紋筋は形態学的にも、機能学的にも特異な特色を示す。収縮メカニズムは異なるが、筋形質内に含まれるアクチンとミオシンの筋原線維が滑り込むことによって収縮すると言える。三筋いずれの組織も再生能は低い。最近では、マウス心筋において、新生や再生を認める報告がある。胚性幹細胞（Embryonic stem cells , ESC）あるいは人工多能性幹細胞（Induced pluripotent stem cells, iPSC）由来の心筋新生に成功し、in vitro での研究では拍動を続けている。もとの心筋組織の一部となり協調して失われた機能を回復させることが大いに期待される。また横紋筋には筋萎縮がみられる。これは、運動器および神経系の障害によることが多いが、両者に共通して、筋形質内にE3 ユビキチンリガーゼが認められる。今後は、これを指標として適切な対応で患者の回復、日常生活への自立、QOL の向上が期待できる。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容種別","attribute_value_mlt":[{"subitem_description":"Review Article","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"大阪河﨑リハビリテーション大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-509X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小西 正良","creatorNameLang":"ja"},{"creatorName":"Masayoshi KONISHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大田 喜一郎","creatorNameLang":"ja"},{"creatorName":"Kiichiro OTA","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-08"}],"displaytype":"detail","filename":"Ｋ06-017-025.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ｋ06-017-025","url":"https://kawasakigakuen.repo.nii.ac.jp/record/76/files/Ｋ06-017-025.pdf"},"version_id":"9508b5a3-a017-4954-98f6-1ebb001dacf6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"平滑筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"委縮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"smooth muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"striated muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"筋組織の再生と委縮","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋組織の再生と委縮","subitem_title_language":"ja"},{"subitem_title":"Regeneration and atrophy of muscle tissues","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"4","path":["19"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-08"},"publish_date":"2020-06-08","publish_status":"0","recid":"76","relation_version_is_last":true,"title":["筋組織の再生と委縮"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-09-29T01:44:29.636416+00:00"}