| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-08-10 |
| タイトル |
|
|
タイトル |
Clinical trials for Alzheimer disease and perspectives |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Alzheimer disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
amyloid β-protein |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
γ-secretase inhibitors |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
BACE inhibitors |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
anti-Aβ antibodies |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| ID登録 |
|
|
ID登録 |
10.69202/0000000304 |
|
ID登録タイプ |
JaLC |
| 内容種別 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Review Article |
| 著者 |
Shinji TAGAMI
Masatoshi TAKEDA
Masayasu OKOCHI
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Alzheimer disease (AD) is the most common type of dementia and may account for 60 - 70% of dementia cases. Senile plaques are a hallmark of AD, and their major constituent is amyloid β-protein (Aβ) 42. Aβ is produced via endoproteolysis by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), which cleaves β-amyloid precursor protein at the extracellular domain, followed by cleavages by presenilin/γ-secretase. Aβ accumulation in the brain is thought to occur decades before disease onset, and pathological changes such as synaptic dysfunction and tau accumulation gradually proceed. Most candidates for disease-modifying therapy (DMT) for AD have targeted either inhibition of Aβ generation with secretase inhibitors or removal of produced and aggregated Aβ with anti-Aβ antibodies. None of them has been approved for clinical practice. Moreover, application of BACE inhibitors and γ-secretase inhibitors in several clinical studies caused paradoxical cognitive impairment. However, early AD patients treated with aducanumab, a monoclonal anti-Aβ antibody, showed a significant reduction in cognitive decline and its clinical use is awaiting approval by the FDA in 2020. In this review, we present a brief summary of DMTs that target Aβ and perspectives for future AD therapy. |
|
言語 |
en |
| 書誌情報 |
en : COGNITION & REHABILITATION
巻 1,
号 1,
p. 12-19,
発行日 2020-12
|
| 出版者 |
|
|
出版者 |
大阪河﨑リハビリテーション大学 |
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2436-1097 |
C 1-012-019 (279.4 kB)
