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内容記述 |
Objectives: To evaluate gait disturbances using a smartphone and reveal the association between gait, muscle strength, and medication in patients with chronic psychiatric disorders. Methods: Chronic psychiatric patients were recruited from March 2019 to February 2020. We evaluated gait velocity, cadence, and stride length through a 10 m walking test (10mWT), and measured three direction acceleration of the body center of gravity (COG) using the iPhone6. The mean vertical (mVA), medio-lateral (mMLA), and antero-posterior (mAPA) amplitude of the relative trajectory of the COG were calculated from the acceleration data using MATLAB R2016a. Grip strength, drug induced extra-pyramidal symptoms scale (DIEPSS), and medication information were collected. Spearman's rank correlation coefficients were used to investigate associations among gait velocity, cadence, stride length, mVA, mMLA, mAPA, grip strength, and chlorpromazine/diazepam/biperiden equivalent doses. The level of statistical significance was set at p < 0.05, and p-values were adjusted using the Benjamini-Hochberg method for multiple comparisons. Results: Fourteen males and six females participated, with 12 having schizophrenia spectrum disorders. The mean (SD) age and grip strength were 66.2 (12.4) years and 24.6 (8.5) kg, respectively. The mean (SD) velocity, cadence, and stride length were 1.0 (0.4) m/sec, 2.0 (0.2) steps/sec, and 0.5 (0.2) m/step, respectively in 10mWT. Velocity and stride length were significantly associated with mVA and mAPA. Velocity, stride length, and mVA were also significantly and positively related to grip strength, but not DIEPSS and medication. Cadence and mMLA were not related to any gait parameters. Diazepam equivalent doses were positively associated with mMLA. Conclusion: Muscle weakness may affect gait disturbances with a small step in chronic psychiatric patients. The results suggest that sarcopenia has an impact on the physical performance of such patients. In addition, benzodiazepine medication may affect the impaired balance in these patients. |
C 1-067-073 (612.3 kB)
