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Pathophysiology of major depressive disorder related to the relationship between inflammation and the nervous system
https://kawasakigakuen.repo.nii.ac.jp/records/316
https://kawasakigakuen.repo.nii.ac.jp/records/3163d9854e1-e4ce-4554-8e1c-f3caf2eff997
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
C 1-090-101 (675.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2021-08-16 | |||||||||
| タイトル | ||||||||||
| タイトル | Pathophysiology of major depressive disorder related to the relationship between inflammation and the nervous system | |||||||||
| 言語 | en | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Major depressive disorder | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Depression | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Inflammatory system | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cytokines | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Interleukin-6 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||||||
| 資源タイプ | other | |||||||||
| 内容種別 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Review Article | |||||||||
| 著者 |
Katsuhiko YAMASAKI
× Katsuhiko YAMASAKI
× Masatoshi TAKEDA
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Major depressive disorder (MDD) is a leading cause of disability. It is associated with the highest disability-adjusted life year (DALY) value among all diseases and disorders, placing a significant burden on society. Thus, new advances in treatment methods based on the pathogenesis of MDD are strongly required. Historically, the monoamine hypothesis has been the major theory of depression, but it is too simplistic. It cannot explain the latency of response in the therapeutic action of antidepressants, and up to 30% of depressed patients fail to achieve remission despite multiple treatment trials. Over the past three decades, research has suggested that inflammatory processes are involved in the onset and maintenance of MDD; the inflammatory hypothesis has been proposed. This review will highlight the association between inflammation and the nervous system and the role of inflammation in the pathogenesis of MDD, including whether chronic stress (e.g., psychosocial stress) activates the inflammatory response, what kind of upstream neurogenic processes translate physiologic stress into inflammatory responses, communication pathways, or mechanisms by which the peripheral immune system can influence the brain and behavior; and the pathophysiology by which inflammation affects the nervous system and leads to MDD. Once cytokine signals reach the brain, they can interact with every pathophysiologic domain relevant to mood regulation, which includes neurotransmitter function, hypothalamic-pituitary-adrenal (HPA) axis activity, neural plasticity, and alteration of brain circuitry. Recent data demonstrating the importance of cytokines as biomarkers will also be presented. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : COGNITION & REHABILITATION 巻 1, 号 1, p. 90-101, 発行日 2020-12 |
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| 出版者 | ||||||||||
| 出版者 | 大阪河﨑リハビリテーション大学 | |||||||||
| 言語 | ja | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 2436-1097 | |||||||||
