| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-12-24 |
| タイトル |
|
|
タイトル |
Association between cognitive decline and decreased serum osteocalcin levels in community-dwelling older people |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cognitive function |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
osteocalcin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
older people |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| ID登録 |
|
|
ID登録 |
10.69202/0000000329 |
|
ID登録タイプ |
JaLC |
| 内容種別 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
| 著者 |
Misa NAKAMURA
Masakazu IMAOKA
Hiroshi HASHIZUME
Fumie TAZAKI
Hidetoshi NAKAO
Mitsumasa HIDA
Tomoko OMIZU
Hideki KANEMOTO
Ichiro KAMEI
Masatoshi TAKEDA
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Many reports show that low bone mineral density and osteoporosis are associated with cognitive impairment and Alzheimer's disease in older women. In addition, bone-related substances such as osteocalcin (OC) and insulin-like growth factor 1 (IGF-1) affect cognitive function. In this study, the aim was to clarify the relationship between changes in cognitive function and changes in serum OC, IGF-1, and albumin levels in community-dwelling older people. The participants were 76 healthy older people living in Japan. They participated in a weekly, local government-supported exercise class for 13 weeks. The Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. Twenty-two participants (28.9%) had decreased MMSE scores at the 13th week. Correlation analysis showed that ΔOC correlated with ΔMMSE score. On analysis of covariance adjusted for baseline values, the cognitive decline group had a significantly greater decrease in OC levels than the no cognitive decline group. The participants with increased ΔOC had lower odds of cognitive decline at the 13th week on logistic regression analysis. These results suggest that there may be a relationship between decreases in serum OC levels and cognitive decline in community-dwelling older people. |
|
言語 |
en |
| 書誌情報 |
en : COGNITION & REHABILITATION
巻 2,
号 1,
p. 20-26,
発行日 2021-11-30
|
| 出版者 |
|
|
出版者 |
大阪河﨑リハビリテーション大学 |
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2436-1097 |
C 2-020-026 (718.9 kB)
